Boosting Brown Fat Through Diet

Sept 26 Boosting Brown Fat copy.jpeg

Until about ten years ago, brown adipose tissue (BAT) was considered to be biologically active only in babies and small children where it generates heat by burning fat. But now, there is no doubt that active brown fat is present in adult humans and is involved in cold-induced increases in whole-body calorie expenditure and, thereby, helps control of not only body temperature but also how fat we are.

In 2013, researchers showed that one could activate brown adipose tissue if you chill out people long enough, specifically, by exposing them to two hours of cold every day for six weeks, which can lead to a significant reduction in body fat. You can see an illustrative graph in my video Boosting Brown Fat Through Diet. Although researchers demonstrated the effective recruitment of human brown fat, it would seem difficult to increase exposure to cold in daily life. Thankfully, our brown fat can also be activated by some food ingredients, such as capsaicin, the compound that makes hot peppers hot.

While physical activity is usually recommended to increase energy expenditure, there are specific food components, such as capsaicin, that are known to burn off calories. For example, one study found that there was a significant rise in energy expenditure within 30 minutes of eating the equivalent of a jalapeño pepper.

Normally when we cut down on calories, our metabolism slows down, undercutting our weight loss attempts; but sprinkling a third of a teaspoon of red chili pepper powder onto our meals counteracts that metabolic slow down and promotes fat burning. Researchers wanted to try giving participants more chili pepper in order to try to match some of the studies done in Asia, but the Caucasian subjects couldn't take it. But by adding more than a tablespoon of red pepper powder to a high-fat meal, Japanese women burned significantly more fat.

We've known for decades that cayenne pepper increases metabolic rate, but we didn't know how. But studies show that this class of compounds increases energy expenditure in human individuals with brown fat, but not in those without it, indicating that individuals increase expenditure right off the BAT. Additionally, there is a variety of structurally similar flavor molecules in other foods, like black pepper and ginger, that may activate thermogenesis as well, but they haven't been directly tested.

All these results suggest that the anti-obesity effects of pepper compounds are based on the heat-generating activity of recruited brown fat. Thus, repeated ingestion can mimic the chronic effects of cold exposure without having to freeze ourselves.

Consumption of spicy foods may help us lose weight, but what about the sensory burn and pain on our tongues and sometimes in our stomachs as well as further on down? Are our only two options for boosting brown fat to freeze our legs or burn our butts?

Arginine-rich foods may also stimulate brown adipose tissue growth and development through a variety of mechanisms, which is achieved by consuming more soy foods, seeds, nuts, and beans.


For more on brown adipose tissue, see Brown Fat: Losing Weight Through Thermogenesis.

What about arginine? Check out Fat Burning Via Arginine. And, did you know arginine may also play a role in the effects nuts may have on penile blood flow? I discuss this in Pistachio Nuts for Erectile Dysfunction.

For more on spicy foods, see my videos Cayenne Pepper for Irritable Bowel Syndrome and Chronic Indigestion to learn how digestive disorders may be helped and Hot Sauce in the Nose for Cluster Headaches? for information on how the hot pepper compound can be a lifesaver for people suffering from "suicide" headaches.

In health,

Michael Greger, M.D.

PS: If you haven't yet, you can subscribe to my free videos here and watch my live, year-in-review presentations:

Original Link

Boosting Brown Fat Through Diet

Sept 26 Boosting Brown Fat copy.jpeg

Until about ten years ago, brown adipose tissue (BAT) was considered to be biologically active only in babies and small children where it generates heat by burning fat. But now, there is no doubt that active brown fat is present in adult humans and is involved in cold-induced increases in whole-body calorie expenditure and, thereby, helps control of not only body temperature but also how fat we are.

In 2013, researchers showed that one could activate brown adipose tissue if you chill out people long enough, specifically, by exposing them to two hours of cold every day for six weeks, which can lead to a significant reduction in body fat. You can see an illustrative graph in my video Boosting Brown Fat Through Diet. Although researchers demonstrated the effective recruitment of human brown fat, it would seem difficult to increase exposure to cold in daily life. Thankfully, our brown fat can also be activated by some food ingredients, such as capsaicin, the compound that makes hot peppers hot.

While physical activity is usually recommended to increase energy expenditure, there are specific food components, such as capsaicin, that are known to burn off calories. For example, one study found that there was a significant rise in energy expenditure within 30 minutes of eating the equivalent of a jalapeño pepper.

Normally when we cut down on calories, our metabolism slows down, undercutting our weight loss attempts; but sprinkling a third of a teaspoon of red chili pepper powder onto our meals counteracts that metabolic slow down and promotes fat burning. Researchers wanted to try giving participants more chili pepper in order to try to match some of the studies done in Asia, but the Caucasian subjects couldn't take it. But by adding more than a tablespoon of red pepper powder to a high-fat meal, Japanese women burned significantly more fat.

We've known for decades that cayenne pepper increases metabolic rate, but we didn't know how. But studies show that this class of compounds increases energy expenditure in human individuals with brown fat, but not in those without it, indicating that individuals increase expenditure right off the BAT. Additionally, there is a variety of structurally similar flavor molecules in other foods, like black pepper and ginger, that may activate thermogenesis as well, but they haven't been directly tested.

All these results suggest that the anti-obesity effects of pepper compounds are based on the heat-generating activity of recruited brown fat. Thus, repeated ingestion can mimic the chronic effects of cold exposure without having to freeze ourselves.

Consumption of spicy foods may help us lose weight, but what about the sensory burn and pain on our tongues and sometimes in our stomachs as well as further on down? Are our only two options for boosting brown fat to freeze our legs or burn our butts?

Arginine-rich foods may also stimulate brown adipose tissue growth and development through a variety of mechanisms, which is achieved by consuming more soy foods, seeds, nuts, and beans.


For more on brown adipose tissue, see Brown Fat: Losing Weight Through Thermogenesis.

What about arginine? Check out Fat Burning Via Arginine. And, did you know arginine may also play a role in the effects nuts may have on penile blood flow? I discuss this in Pistachio Nuts for Erectile Dysfunction.

For more on spicy foods, see my videos Cayenne Pepper for Irritable Bowel Syndrome and Chronic Indigestion to learn how digestive disorders may be helped and Hot Sauce in the Nose for Cluster Headaches? for information on how the hot pepper compound can be a lifesaver for people suffering from "suicide" headaches.

In health,

Michael Greger, M.D.

PS: If you haven't yet, you can subscribe to my free videos here and watch my live, year-in-review presentations:

Original Link

Pistachios May Help Erectile Dysfunction

Pistachios May Help Erectile Dysfunction

Erectile dysfunction is a major cause of decreased quality of life in men—so much so that one early theory suggested that this may explain the link between impotence and heart attacks. Depression is a risk factor for coronary heart disease, and the thought was that men who couldn’t get it up become so depressed that they die of a broken heart.

Now we know that erectile dysfunction and heart disease can be two different manifestations of the exact same root problem, diseased arteries—inflamed, oxidized, cholesterol-clogged blood vessels (See Survival of the Firmest: Erectile Dysfunction and Death). So it’s no wonder that a diet chock-full of anti-inflammatory, antioxidant, cholesterol-lowering plant foods would improve sexual functioning in both men and women, as well as reduce the risk of heart disease (See 50 Shades of Green). A completely plant-based diet can even stop and reverse our number one killer (See One in a Thousand: Ending the Heart Disease Epidemic).

Of all the plant foods individually examined so far, nuts appear most tied to longevity. Just two handfuls a week may extend a woman’s life as much as jogging four hours a week (see What Women Should Eat to Live Longer). So, if nuts reduce the risk of heart disease, might they also help with sexual dysfunction?

In my video, Pistachio Nuts for Erectlie Dysfuntion I outline a study where men eating three to four handfuls of pistachios a day for just three weeks experienced both significant improvement in blood flow through the penis and significantly firmer erections. This is not surprising. Antioxidant-rich foods have a Viagra-like effect of boosting nitric oxide production. (See The Power of NO). Also, the citruline in watermelons helped with erection firmness by boosting arginine, (See Watermelon as Treatment for Erectile Dysfunction), which is what our body makes nitric oxide out of.Pistachios have a bunch of both antioxidants and arginine, which may help explain the improvement in blood flow.

We also know that cholesterol is an important predictor of sexual dysfunction in both men and women (See Cholesterol and Female Sexual Dysfunction), and after just three weeks, those eating pistachios had significant improvements in cholesterol. And like other studies that piled on hundreds of calories of nuts a day, there was no weight gain. (For more on this remarkable effect, see my videos Nuts and Obesity: The Weight of Evidence, Solving the Mystery of the Missing Calories, and Testing the Pistachio Principle). Conclusion: “Just three weeks of pistachios resulted in a significant improvement in erectile function with additional improvement in cholesterol without any side effects.”

Note the two important differences between diet and drugs. Drugs like Viagra just cover up the symptoms of the underlying problem–unhealthy arteries. Eating whole healthy plant foods like nuts actually helps attack the root cause—cholesterol, oxidation, and inflammation—and has only good side effects.

The enzyme that Viagra-like drugs inhibit is found primarily in two places in the body: the erectile tissue of the penis and the retina of the eye. That’s why the FDA encourages people to stop taking drugs like Viagra, and “call a doctor right away if you experience sudden loss of vision.” (Assuming you can still find your phone.)

Though the harms (such as cyanopsia in which everything in our vision suddenly becomes tinted blue) tend to be self-limited and reversible, why risk side-effects at all when the problem can be reversed and cured in the first place, improving the quality and quantity of our lives?

I discuss the epidemic of adverse prescription drug side-effects in my 2012-13 annual review Uprooting the Leading Causes of Death and my new 2013-14 live presentation More Than an Apple a Day: Combating Common Diseases.

In addition to improving penile blood flow, nuts may also help prevent breast cancer (Tree Nuts or Peanuts for Breast Cancer Prevention?), inflammatory diseases (Fighting Inflammation in a Nut Shell), sudden death (How Do Nuts Prevent Sudden Cardiac Death?), and lengthen one's lifespan (Nuts May Help Prevent Death). 

-Michael Greger, M.D.

PS: If you haven’t yet, you can subscribe to my free videos here.

Image Credit: miss iona lion / Flickr

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